Galactorrhea-amenorrhea syndrome is caused by a hormonal imbalance in the body. The most common cause of this condition is the combination of low thyroid and high estrogen levels. This can be caused by external factors, such as stress or dieting, or it can be caused by internal factors, such as tumors or genetic disorders.
The following risk factors can increase your chances of developing galactorrhea-amenorrhea syndrome:
- Age: The disorder is most likely to occur in women aged 20-40 years old.
- Family history: If someone in your family has galactorrhea-amenorrhea syndrome, your risk of also developing it increases.
- Diabetes: Women with diabetes have an increased risk of developing galactorrhea-amenorrhea syndrome.
- Breast enlargement (galactorrhea)
- Milky discharge from breast (galactorrhea)
- Inability to conceive a child (amenorrhea)
- Missed periods or irregular periods (amenorrhea)
- Cancers that produce hormones or affect hormone production
- Brain tumors or other neurologic conditions that affect the pituitary gland
- Infections that cause inflammation in the pituitary gland or hypothalamus
- Inflammation from autoimmune diseases such as lupus erythematosus, rheumatoid arthritis, and sarcoidosis
- Previous exposure to radiation therapy or chemotherapy
- Pregnancy complications like preterm labor or placenta previa (when the placenta covers part of the cervix)
- Pregnancy after age 40 or after having had a hysterectomy
- Family history of autoimmune diseases (like lupus or rheumatoid arthritis)
- A hormonal imbalance is the most common cause of galactorrhea-amenorrhea syndrome. This imbalance can be caused by an overactive thyroid gland (hyperthyroidism), which increases levels of the hormones thyroxine and triiodothyronine.
- Other hormonal imbalances that may cause galactorrhea-amenorrhea syndrome include prolactinoma (a tumor on your pituitary gland), polycystic ovarian syndrome (PCOS), adrenal hyperplasia, hypogonadism, or excess progesterone.
- Some medications can also cause galactorrhea-amenorrhea syndrome: these include antipsychotics, antidepressants, birth control pills, corticosteroids, thyroid medications and lithium carbonate.
Infections such as meningitis or encephalitis,Sleep disorders like narcolepsy and sleep apnea,Extreme stress,Seizures,Surgery on the hypothalamus or pituitary gland
Common vaginal infection caused by an overgrowth of bacteria
Bromocriptine,Chlorpromazine,Clomipramine,Gonadotropin releasing hormone agonists (GnRH agonist)